Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors with somatostatin analogues.
نویسندگان
چکیده
BACKGROUND Clinical experience with the radiolabeled somatostatin analogues 90Y-DOTATOC and, more recently, 177Lu-DOTATATE, is ongoing since more than a decade in few centers. Dosimetric studies demonstrated that 90Y-DOTATOC and 177Lu-DOTATATE are able to deliver high doses to somatostatin receptor sst2-expressing tumors and low doses to normal organs. RESULTS AND CONCLUSIONS Clinical studies demonstrated that partial and complete objective responses in up to 30% of patients can be obtained, with a great survival benefit in treated patients. Side effects may involve the kidney and the bone marrow and are usually mild. Renal protection is used to minimize the risk of a late decrease of renal function.
منابع مشابه
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ورودعنوان ژورنال:
- European review for medical and pharmacological sciences
دوره 14 4 شماره
صفحات -
تاریخ انتشار 2010